Anticonvulsant Medications in Mitochondrial Disease
نویسندگان
چکیده
منابع مشابه
Anticonvulsant Medications in Mitochondrial Disease
Researchers from Vienna, Austria and Sao Paulo, Brazil studied the known effects of anticonvulsant drugs on mitochondria, using a literature search to include only references to epilepsy associated with mitochondrial disease, and a specific anti-convulsant drug (i.e. levetiracetam) with a specific mitochondrial function (i.e. mitochondrial membrane potential).
متن کاملAssessing epidemiological evidence for the teratogenic effects of anticonvulsant medications.
pidemiological studies of pregnancy outcomes of women with epilepsy are important, primarily to inform choice of treatment options in clinical care of pregnant women and to inform counselling, the need for prenatal and postnatal screening, and the need for early medical, behavioural, or educational intervention. In this issue (page 251), Dean et al report on a long term follow up of the health ...
متن کاملSulforaphane is anticonvulsant and improves mitochondrial function.
The nuclear factor erythroid 2-related factor 2 pathway (Nrf2) has been previously identified to protect the brain against various impacts. Here, we investigated the effect of the Nrf2 activator sulforaphane in various seizure models and hippocampal mitochondrial bioenergetics. We found that daily injections of sulforaphane for 5 days elevated the seizure thresholds to 6 Hz stimulation and fluo...
متن کاملMitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet.
OBJECTIVE The full anticonvulsant effect of the ketogenic diet (KD) can require weeks to develop in rats, suggesting that altered gene expression is involved. The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies in adolescent rats to understand its anticonvulsant effect. METHODS Microar...
متن کاملSpecific safety and tolerability considerations in the use of anticonvulsant medications in children
Epilepsy is one of the most common neurological disorders in the pediatric age range, and the majority of affected children can be safely and effectively treated with antiepileptic medication. While there are many antiepileptic agents on the market, specific drugs may be more efficacious for certain seizure types or electroclinical syndromes. Furthermore, certain adverse effects are more common...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 2017
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-31-3-3